ABSTRACT
Title
Specific neuromodulatory actions of beta-amyloid: novel mechanisms
Authors
M. Grilli1, S. Zappettini1, E. Mura3, S. Preda3, S.Govoni3 and M. Marchi1,2
1Section of Pharmacology and Toxicology, Department of Experimental Medicine, University of Genoa, Genoa, Italy; 2Center of Excellence for Biomedical Research, University of Genoa, Italy; 3Dept. of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia , Italy
1Section of Pharmacology and Toxicology, Department of Experimental Medicine, University of Genoa, Genoa, Italy; 2Center of Excellence for Biomedical Research, University of Genoa, Italy; 3Dept. of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia , Italy
Abstract
Beta amyloid peptides are produced in high amount during Alzheimer’s disease but they are also produced by normal brain cells and found in pico-nano molar range in the cerebrospinal fluid of healthy individuals. Therefore the possibility that they might have a neuromodulatory role in the regulation of normal synaptic function it’s likely to occur. In this presentation we report an extension of recent data concerning the effects of beta amyloid peptides on neurotransmitter release in the rat CNS.
Using in vivo and in vitro approaches we demonstrated that beta amyloid can affect the cholinergic control of neurotransmitters release in different brain areas (Preda et al. 2008; Mura et al. 2010; Grilli et al. 2010). These findings may be relevant both for the definition of the putative physiological modulatory role of beta amyloid peptides and for the understanding, even before the neurodegenerative phase, of the molecular bases of the disruption of neurotransmitter function in Alzheimer’ disease.
Preda S., Govoni S., Lanni C., Racchi M., Mura E., Grilli M. and Marchi M.
Acute b-Amyloid Administration Disrupts the Cholinergic Control of Dopamine Release in the Nucleus Accumbens. Neuropsychopharmacology Volume 33, Issue 5 2008, Pages 1062-1070
Mura E., Preda S., Govoni S., Lanni C., Trabace L., Grilli M., Lagomarsino F., Pittaluga A. and Marchi M.
Specific neuromodulatory actions of Beta-Amyloid on dopamine release in motor versus emotional control areas of rat brain.J Alzheimers Dis Volume 19, Issue 3, 2010, 1041-1053
Grilli M, Lagomarsino F, Zappettini S, Preda S, Mura E, Govoni S, Marchi M.
Specific inhibitory effect of amyloid-beta on presynaptic muscarinic receptor subtypes modulating neurotransmitter release in the rat nucleus accumbens.
Neuroscience. 2010 May 5;167(2):482-9. Epub 2010 Feb 9
This work was supported by grants from the Italian Ministero Università Ricerca to Prof. Stefano Govoni and Mario Marchi (prot. N° 2007HJCCSF, prot. N° 20072BTSR2_002 ), from Compagnia di San Paolo and from University of Genoa ‘Progetto Ricerca Ateneo’ to Prof. Mario Marchi.
Using in vivo and in vitro approaches we demonstrated that beta amyloid can affect the cholinergic control of neurotransmitters release in different brain areas (Preda et al. 2008; Mura et al. 2010; Grilli et al. 2010). These findings may be relevant both for the definition of the putative physiological modulatory role of beta amyloid peptides and for the understanding, even before the neurodegenerative phase, of the molecular bases of the disruption of neurotransmitter function in Alzheimer’ disease.
Preda S., Govoni S., Lanni C., Racchi M., Mura E., Grilli M. and Marchi M.
Acute b-Amyloid Administration Disrupts the Cholinergic Control of Dopamine Release in the Nucleus Accumbens. Neuropsychopharmacology Volume 33, Issue 5 2008, Pages 1062-1070
Mura E., Preda S., Govoni S., Lanni C., Trabace L., Grilli M., Lagomarsino F., Pittaluga A. and Marchi M.
Specific neuromodulatory actions of Beta-Amyloid on dopamine release in motor versus emotional control areas of rat brain.J Alzheimers Dis Volume 19, Issue 3, 2010, 1041-1053
Grilli M, Lagomarsino F, Zappettini S, Preda S, Mura E, Govoni S, Marchi M.
Specific inhibitory effect of amyloid-beta on presynaptic muscarinic receptor subtypes modulating neurotransmitter release in the rat nucleus accumbens.
Neuroscience. 2010 May 5;167(2):482-9. Epub 2010 Feb 9
This work was supported by grants from the Italian Ministero Università Ricerca to Prof. Stefano Govoni and Mario Marchi (prot. N° 2007HJCCSF, prot. N° 20072BTSR2_002 ), from Compagnia di San Paolo and from University of Genoa ‘Progetto Ricerca Ateneo’ to Prof. Mario Marchi.